Secretomes of apoptotic mononuclear cells ameliorate neurological damage in rats with focal ischemia
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منابع مشابه
Secretomes of apoptotic mononuclear cells ameliorate neurological damage in rats with focal ischemia
The pursuit of targeting multiple pathways in the ischemic cascade of cerebral stroke is a promising treatment option. We examined the regenerative potential of conditioned medium derived from rat and human apoptotic mononuclear cells (MNC), rMNC (apo sec) and hMNC (apo sec), in experimental stroke. We performed middle cerebral artery occlusion on Wistar rats and administered apoptotic MNC-secr...
متن کاملSecretomes of apoptotic mononuclear cells ameliorate neurological damage in rats with focal ischemia [version 2; referees: 1 approved, 2 approved with reservations]
The pursuit of targeting multiple pathways in the ischemic cascade of cerebral stroke is a promising treatment option. We examined the regenerative potential of conditioned medium derived from rat and human apoptotic mononuclear cells (MNC), rMNC and hMNC , in experimental stroke. We performed middle cerebral artery occlusion on Wistar rats and administered apoptotic MNC-secretomes intraperiton...
متن کاملNeurological and behavioral outcomes of focal cerebral ischemia in rats.
BACKGROUND AND PURPOSE The aim of this study was to investigate the neurobehavioral consequences of focal ischemia in rats. METHODS We induced permanent occlusion of the left middle cerebral artery in 14 Sprague-Dawley rats, and used 13 sham-operated rats as controls. During surgery, brain temperature and body temperature were kept at normothermia. Neurobehavioral studies (neurological examin...
متن کاملTemporal and spatial profile of apoptotic cells after focal cerebral ischemia in rats.
The significance of apoptosis in focal ischemia was investigated in the spatial and temporal profiles of apoptotic cells caused by permanent and transient focal ischemia induced in male Wistar rats by intraluminal vascular occlusion. Animals were sacrificed at various times and coronal sections of the brain at the level of the optic chiasm were examined histologically by terminal deoxynucleotid...
متن کاملInhibition of nitric oxide synthase activity improves focal cerebral damage induced by cerebral ischemia/reperfusion in normotensive rats
Introduction: Nitric oxide seems to play a dual role in ischemia/reperfusion injury. Few studies have investigated whether it exacerbates or improves brain edema. In the present study, we inhibited the activity of nitric oxide synthase by L-NAME and evaluated the cerebral infarct volume, tissue swelling and brain edema, alongside the measurement of blood flow of the ischemic region. Methods...
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ژورنال
عنوان ژورنال: F1000Research
سال: 2014
ISSN: 2046-1402
DOI: 10.12688/f1000research.4219.2